For those of you that have pups from Spice and Wyatt they will all be MDR1 Normal/Normal
Wyatt is N/N and Spice is N/N
Those pups are cleared by parentage.
If you would like copies of Wyatt’s and Spice’s test results just let me know, and I can email them to you .
Explanation of test results
These dogs do not carry the mutation, and will not pass on the mutation to their offspring.These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium®), and some anticancer drugs.
These dogs carry the mutation and can not pass on a normal gene to their offspring.These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).
These dogs carry the mutation and may pass on the mutant gene to their offspring.These dogs may experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).
MDR1 Breeding Pair Combinations and Outcomes
|Normal/Normal Male||Normal/Mutant* Male||Mutant/Mutant Male|
|Normal/Normal Female||100% Normal/Normal puppies||Normal/Normal and/or Normal/Mutant puppies||100% Normal/Mutant puppies|
|Normal/Mutant* Female||Normal/Normal and/or Normal/Mutant puppies||Any combination of puppies||Normal/Mutant and/or Mutant/Mutant puppies|
|Mutant/Mutant Female||100% Normal/Mutant puppies||Normal/Mutant and/or Mutant/Mutant puppies||100% Mutant/Mutant puppies|
For more info go to; http://www.vetmed.wsu.edu/depts-VCPL/index.aspx