MDR1

For those of you that have pups from Spice and Wyatt they will all be MDR1  Normal/Normal

Wyatt is N/N and Spice is N/N

Those pups are cleared by parentage.

If you would like copies of Wyatt’s and Spice’s  test results just let me know, and I can email them to you .

Explanation of test results

Normal/Normal

These dogs do not carry the mutation, and will not pass on the mutation to their offspring.These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium®), and some anticancer drugs.

Mutant/Mutant

These dogs carry the mutation and can not pass on a normal gene to their offspring.These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).

Mutant/Normal

These dogs carry the mutation and may pass on the mutant gene to their offspring.These dogs may experience toxicity after normal doses of loperamide (Imodium®), some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).

MDR1 Breeding Pair Combinations and Outcomes

Normal/Normal Male Normal/Mutant* Male Mutant/Mutant Male
Normal/Normal Female 100% Normal/Normal puppies Normal/Normal and/or Normal/Mutant puppies 100% Normal/Mutant puppies
Normal/Mutant* Female Normal/Normal and/or Normal/Mutant puppies Any combination of puppies Normal/Mutant and/or Mutant/Mutant puppies
Mutant/Mutant Female 100% Normal/Mutant puppies Normal/Mutant and/or Mutant/Mutant puppies 100% Mutant/Mutant puppies

For more info go to; http://www.vetmed.wsu.edu/depts-VCPL/index.aspx

Categories: Wyatt And Spice's Puppies | Tags: , ,

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